You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-GATA Binding Protein-GATA4-IN-3
GATA4-IN-3

Chemical Structure : GATA4-IN-3

CAS No.: 544681-96-1

GATA4-IN-3 (GATA4 inhibitor 3)

Catalog No.: PC-61050Not For Human Use, Lab Use Only.

GATA4-IN-3 is a novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation.

Packing Price Stock Quantity
5 mg $188 In stock
10 mg $328 In stock
25 mg $528 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GATA4-IN-3 is a novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation.
GATA4-IN-3 also inhibits the ET-1-stimulated BNP gene expression.
GATA4-IN-3 inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death.

Physicochemical Properties

M.Wt 349.434
Formula C21H23N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

References

1. Välimäki MJ, et al. J Med Chem. 2017 Sep 28;60(18):7781-7798.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: