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Cat. No. Product Name CAS No. Information
PC-63247

3i-1000

544681-96-1 3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM; inhibits cardiac gene expression induced by mechanical stretch and phenylephrine, such as ANP and BNP, without significantly influencing the baseline mRNA levels, inhibits hypertrophic process in cardiomyocytes in vitro; significantly inhibits PE-induced elevation in GATA4 Ser-105 phosphorylation in neonatal rat cardiomyocytes; promotes myocardial repair in experimental model of myocardial ischemia reperfusion injury.
PC-61051

GATA4 activator 7

878090-53-0 A novel small molecule that activates GATA4/NKX2-5 transcriptional synergy with EC50 of 7 uM in cell reporter assay.
PC-61050

GATA4-IN-3

544681-96-1 A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation; also inhibits the ET-1-stimulated BNP gene expression, and inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death.
PC-43169

K-7174 dihydrochloride

191089-60-8 A selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2); suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro; induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1; significantly decreases HAMP expression, also upregulates CEBPB.
PC-43168

K-7174

191089-59-5 A selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2); suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro; induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1; significantly decreases HAMP expression, also upregulates CEBPB.

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