Chemical Structure : GD433
CAS No.:
2892821-66-6
GD433
(GD-433)
Catalog No.: PC-26565Not For Human Use, Lab Use Only.
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM.
GD433 interacts with NTMT1 with a dissociation constant (Kd) of 36.9 nM.
GD433 is selective for NTMT1/2 over 40 other methyltransferases (G9a, PRMT1, PRMT7, NNMT, and SETD7).
GD433 potently inhibits NTMT1 and its close homolog NTMT2.
GD433 significantly reduces me3-RCC1 and me3-SET with an approximate IC50 value of <30 nM in HEK293 cells.
GD433 promotes myogenic differentiation and enhances muscle regeneration in mdx mice.
Physicochemical Properties
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M.Wt
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405.49
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Formula
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C20H24FN3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-quinuclidin-3-yl (2-(2-(4-fluoro-3-hydroxyphenyl)thiazol-4-yl)propan-2-yl)carbamate
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References
1. Deng Y, et al. J Med Chem. 2023 Jan 26;66(2):1601-1615.
2. Zhang H, et al. Stem Cell Res Ther. 2026 Apr 15;17(1):139.
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