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Chemical Structure : GDC-046
CAS No.: 1258292-64-6
Catalog No.: PC-38049Not For Human Use, Lab Use Only.
GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 50 mg | $798 | In stock | |
| 100 mg | $1280 | In stock |
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GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively.
GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) in cell based assays.
GDC-046 also displays less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM), and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM).
GDC-046 shows statistically significant knockdown of cytokine interferon-γ (IFNγ), in a mouse IL-12 PK/PD model.
| M.Wt | 350.199 | |
| Formula | C16H13Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide |
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