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GDC-0575

Chemical Structure : GDC-0575

CAS No.: 1196541-47-5

GDC-0575 (ARRY-575;RG-7741;GDC0575)

Catalog No.: PC-60276Not For Human Use, Lab Use Only.

GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.

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25 mg $198 In stock
50 mg $348 In stock
100 mg $558 In stock
200 mg $758 In stock
1 g $758 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
GDC-0575 (ARRY-575, RG-7741) enhances the killing of primary AML cells ex vivo by inducing apoptosis combined with AraC, blocks the activation of CHK1 induced by AraC via decrease in the level of Tyr15-phosphorylated CDK2 at 100 nM in AML cells.

Physicochemical Properties

M.Wt 377.286
Formula C17H21BrN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-indol-3-yl)cyclopropanecarboxamide

References

1. Duan W, et al. Front Oncol. 2014 Dec 19;4:368.

2. Di Tullio A, et al. Nat Commun. 2017 Nov 22;8(1):1679.

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