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Chemical Structure : GGTI-2147
Catalog No.: PC-62471Not For Human Use, Lab Use Only.
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).
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GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).
GGTI-2147 inhibits glucose- and KCl-induced insulin secretion.
GGTI-2147 inhibits Rac1 geranylgeranylation, down-regulates the expression of p65, and ameliorated the OGD/R-induced neuronal apoptosis.
| M.Wt | 470.6 | |
| Formula | C28H30N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vasudevan A, et al. J Med Chem. 1999 Apr 22;42(8):1333-40.
2. Amin R, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.
3. Gao S, et al. Neuropharmacology. 2016 Apr;103:44-56.
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