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Chemical Structure : GGTI-286 hydrochloride
Catalog No.: PC-62473Not For Human Use, Lab Use Only.
GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.
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GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.
GGTI-286 inhibits processing of the geranylgeranylated protein Rap1A.
GGTI-286 inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM.
GGTI-286 reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells.
GGTI-286 has significant antiproliferative effect in human malignant glioma cells.
| M.Wt | 466.037 | |
| Formula | C23H32ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26770-3.
2. Nishiya N, et al. Chem Biol. 2014 Apr 24;21(4):530-40.
3. Lerner EC, et al. Oncogene. 1997 Sep;15(11):1283-8.
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