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Chemical Structure : GGTI298
CAS No.: 180977-44-0
Catalog No.: PC-42281Not For Human Use, Lab Use Only.
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $88 | In stock | |
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).
GGTI298 induces G0-G1 block and apoptosis in A549 cells.
| M.Wt | 479.63422 | |
| Formula | C27H33N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester |
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1. McGuire TF, et al. J Biol Chem. 1996 Nov 1;271(44):27402-7.
2. Miquel K, et al. Cancer Res. 1997 May 15;57(10):1846-50.
3. Vogt A, et al. J Biol Chem. 1997 Oct 24;272(43):27224-9.
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