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Chemical Structure : GI-530159
Catalog No.: PC-62092Not For Human Use, Lab Use Only.
GI-530159 (ICA-069771) is a novel potent, selective, mechano-sensitive K2P channel (TERK) opener with EC50 of 1 uM for TERK1.
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GI-530159 (ICA-069771) is a novel potent, selective, mechano-sensitive K2P channel (TERK) opener with EC50 of 1 uM for TERK1; shows no activator effects on other potassium channels TASK2, KCNQ1, KCNQ2, KCNQ3 using Rb+ efflux assays or against NaV1.2, NaV1.7 and NaV1.8 (EC50>100 uM); enhances TREK2 channels at 1 uM about 42 ± 6 %, but without effect on TRAAK and TASK3 channels; shows a significant reduction in firing frequency and a small hyperpolarization of resting membrane potential in cultured rat DRG neurones.
| M.Wt | 518.459 | |
| Formula | C27H20F6N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Loucif AJC, et al. Br J Pharmacol. 2017 Nov 18. doi: 10.1111/bph.14098.
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