GI-Y2 | GSDMD inhibitor | Probechem Biochemicals

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Chemical Structure : GI-Y2

GI-Y2 (GSDMD inhibitor Y2)

Catalog No.: PC-24520Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GI-Y2 (GSDMD inhibitor Y2) is a specific small molecule inhibitor of Gasdermin D (GSDMD), directly interacts with the Arg10 residue of GSDMD (SPR KD=36.0 uM) and reduces the membrane binding of N-terminal domain (GSDMD‐N).
GI-Y2 directly interacts with the Arg10 residue of GSDMD and reduces the membrane binding of GSDMD-N.
GI-Y2 inhibits the formation of atherosclerotic plaques by targeting GSDMD.
GI-Y2 reduces pyroptosis and macrophage infiltration in atherosclerosis.

Physicochemical Properties

M.Wt	386.38
Formula	C18H14N2O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-(4-carboxybenzyl)-2,4-dioxothiazolidin-5-yl)amino)benzoic acid

References

1. Mei Y, et al. Br J Pharmacol. 2025 Mar 31. doi: 10.1111/bph.70040.

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GI-Y2 (GSDMD inhibitor Y2)

Biological Activity

Physicochemical Properties

References

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