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Chemical Structure : GIBH-130
Catalog No.: PC-60175Not For Human Use, Lab Use Only.
A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM).
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A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM); modulates the release of detrimental proinflammatory cytokines; exhibits in vivo efficacy of cognitive impairment in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models.
Alzheimer's Disease
Phase 1 Clinical
| M.Wt | 360.421 | |
| Formula | C20H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhou W, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.
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