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GLUT4-IN-17

Chemical Structure : GLUT4-IN-17

CAS No.: 1061081-61-5

GLUT4-IN-17

Catalog No.: PC-60884Not For Human Use, Lab Use Only.

A potent, selective glucose transporter 4 (GLUT4) inhibitor with IC450 of 10.8 uM, inhibits MM cell proliferation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GLUT4-IN-17 is a potent, selective glucose transporter 4 (GLUT4) inhibitor with IC450 of 10.8 uM, inhibits MM cell proliferation.
    GLUT4-IN-17 reduces ATB-BMPA binding to GLUT4 to a much greater extent than to GLUT1, inhibits 2-DOG uptake in GLUT4-expressing cells.

    Physicochemical Properties

    M.Wt 509.654
    Formula C31H35N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (3-((3-((methyl(quinolin-6-ylmethyl)amino)methyl)phenoxy)methyl)piperidin-1-yl)(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methanone

    References

    1. Mishra RK, et al. J Biol Chem. 2015 Jun 5;290(23):14441-53.

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