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Chemical Structure : GMFBI.1
Catalog No.: PC-72080Not For Human Use, Lab Use Only.
GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.
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GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.
GMFBI.1 inhibits PKA mediated phosphorylation of hGMF-β substrate in vitro and is non-toxic at lower concentrations on astrocyte cultures, significantly suppresses GMF-β phosphorylation on Ser83 at 250ng/mL (1.68uM).
GMFBI.1 reduces p38MAPK phosphorylation and NFκB expression levels in GMF-β overexpressing LPS induced astrocytes in vitro.
GMFBI.1 inhibitor reversed EAE and suppressed the proinflammatory response in severely paralyzed EAE animals.
| M.Wt | 148.165 | |
| Formula | C8H8N2O | |
| Appearance | Solid | |
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1. Jane Jose Vattathara, et al. Sci Rep. 2020 Mar 2;10(1):3790.
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