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Chemical Structure : GNE-0439
CAS No.: 1241902-40-8
Catalog No.: PC-62325Not For Human Use, Lab Use Only.
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).
GNE-0439 also inhibits mutant N1742K channels with IC50 of 0.37 uM in membrane potential assays, but not mutation of R1608A (IC50>50 uM).
GNE-0439 is unique compared with known selective VSD4 binders such as the arylsulfonamides (GX-936 and PF-05089771).
| M.Wt | 345.483 | |
| Formula | C21H31NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-(4-propylcyclohexyl)benzoyl)-L-valine |
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1. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.
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