Catalog No.: PC-21166Not For Human Use, Lab Use Only.
GNE-235 (GNE235) is a potent, selective inhibitor of the second bromodomain of polybromo-1 (PBRM1; BAF180; PB1) with KD value of 0.28 uM in BROMOscan assays.
GNE-235 (GNE235) is a potent, selective inhibitor of the second bromodomain of polybromo-1 (PBRM1; BAF180; PB1) with KD value of 0.28 uM in BROMOscan assays.
GNE-235 displays >20-fold selectivity over PBRM1(5), SMARCA2 and SMARCA4 in BROMOscan assays.
GNE-235 has binding KD value of 1.1 uM against PBRM1(2) in ITC assays, >30-fold selectivity over PBRM1(4) and PBRM1(3).
GNE-235 also shows clear profiles in the nuclear receptor assays, and the low-level PXR activation.
