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Chemical Structure : GNE-955
Catalog No.: PC-63140Not For Human Use, Lab Use Only.
GNE-955 (GNE955) is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
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GNE-955 (GNE955) is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
GNE-955 shows only 3 kinases >80% inhibition (Pim-1, 100%; CLK1, 97%; Flt3, 82%) at 0.1 uM in a panel of 70 kinases.
GNE-955 shows excellent bioavailability in rat.
| M.Wt | 415.501 | |
| Formula | C23H25N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang X, et al. J Med Chem. 2017 May 25;60(10):4458-4473.
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