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Chemical Structure : GNI-50
Catalog No.: PC-73040Not For Human Use, Lab Use Only.
GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.
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GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.
GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).
| M.Wt | 402.469 | |
| Formula | C19H22N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37.
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