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Chemical Structure : GPR101 agonist AA-14
Catalog No.: PC-21343Not For Human Use, Lab Use Only.
GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively.
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GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively.
AA-14 selectively activated the Gs and Gq pathways downstream of GPR101, but not in HEK293 cells expressing any of the other tested receptors.
AA-14 partially restores the functions of GH/IGF-1 axis.
AA-14 (0.1 mg/kg per day) exerts rejuvenating effects through activating GPR101 in 8-week-old mic, which are abrogated in Gpr101-deficient mice.
AA-14 stimulates hormone synthesis in the pituitary of aged mice.
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis.
| M.Wt | 311.33 | |
| Formula | C14H12F3N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang Z, et al. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01456-6.
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