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Chemical Structure : GPR40 AgoPAM AP5
Catalog No.: PC-35510Not For Human Use, Lab Use Only.
GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
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GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
AP5 demonstrates excellent in vivo efficacy with a projected human dose of 7-15 mg, shows sustained glucose lowering effect in vivo.
| M.Wt | 461.533 | |
| Formula | C28H28FNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen HY, et al. ACS Med Chem Lett. 2018 Jun 14;9(7):685-690.
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