GPR40 agonist K-757

Chemical Structure : GPR40 agonist K-757

Catalog No.: PC-25130Not For Human Use, Lab Use Only.

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).
K-757 is selective against panel of 80 enzymes, receptors, and ion channels.
K-757 (10 mg/kg) elicited GLP-1 secretion in crypt cultures derived from wild-type mice but not from GPR40 knockout mice, induced secretion of both GLP-1 and PYY in human crypts.

Physicochemical Properties

M.Wt	541.71
Formula	C32H48NO4P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-2-Cyclopropyl-2-(3-((1-(2-(4,4-dimethylpentyl)-5-methoxyphenyl)piperidin-4-yl)methoxy)phenyl)ethyl)(methyl)phosphinic Acid

References

1. Moyes CR, et al. J Med Chem. 2025 Jul 24. doi: 10.1021/acs.jmedchem.5c01030.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com