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Chemical Structure : GPR52 antagonist E7
Catalog No.: PC-72129Not For Human Use, Lab Use Only.
GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM.
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GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM.
GPR52 antagonist E7 did not block cAMP elevation induced by Gαs-coupled GPCRs, including β2AR, GCGR and GLP-1R.
GPR52 antagonist E7 reduces mutant HTT levels and rescues Huntington's disease-associated phenotypes in cellular and mouse models.
GPR52 antagonist E7 acts as an tntracellular covalent ligand of orphan receptor GPR52.
| M.Wt | 358.39 | |
| Formula | C20H22O6 | |
| Appearance | Solid | |
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1. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798.
2. Ma M, et al. ACS Chem Biol. 2020 Dec 18;15(12):3275-3284.
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