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Chemical Structure : GPR54 antagonist 15a
Catalog No.: PC-21175Not For Human Use, Lab Use Only.
GPR54 antagonist 15a is a potent, selective, small molecule antagonist of GPR54 with IC50 of 3.6/15 nM (human/rat GPR54) in receptor binding assays.
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GPR54 antagonist 15a is a potent, selective, small molecule antagonist of GPR54 with IC50 of 3.6/15 nM (human/rat GPR54) in receptor binding assays.
GPR54 antagonist 15a exhibits fully potent antagonist activity (IC50=0.93 μM) in cellular Ca2+ mobilization assays.
GPR54 antagonist 15a (0.22 mg/kg, i.v.) suppressed the plasma luteinizing hormone (LH) level in castrated male rats.
| M.Wt | 519.96 | |
| Formula | C27H23ClFN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kobayashi T, et al. Bioorg Med Chem. 2010 Jul 15;18(14):5157-71.
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