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GPR7 antagonist 21a

Chemical Structure : GPR7 antagonist 21a

CAS No.: 2648124-49-4

GPR7 antagonist 21a

Catalog No.: PC-38613Not For Human Use, Lab Use Only.

GPR7 antagonist 21a is a highly potent small molecule antagonist of NPBWR1 antagonist with cAMP IC50 of 30 nM, dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GPR7 antagonist 21a is a highly potent small molecule antagonist of NPBWR1 antagonist with cAMP IC50 of 30 nM, dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding assays.

Physicochemical Properties

M.Wt 397.182
Formula C17H9Cl2F3N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2,6-dichloro-4-(1H-pyrazol-4-yl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

References

1. Remond Moningka, et al. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127510.

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