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Chemical Structure : GPS167
CAS No.:
Catalog No.: PC-73373Not For Human Use, Lab Use Only.
GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
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|---|---|---|---|
| 2 mg | $188 | In stock | |
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
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GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.
GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.
GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.
GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.
| M.Wt | 335.385 | |
| Formula | C17H13N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(1H-indazol-5-yl)-2-(phenylamino)thiazole-4-carboxamide |
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1. Muhammad Sohail, et al. NAR Cancer. 2021 May 25;3(2):zcab019.
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