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Chemical Structure : GQ352
Catalog No.: PC-47039Not For Human Use, Lab Use Only.
GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.
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GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.
GQ352 inhibits uveal melanoma (UM) tumorigenesis by suppressing Gαq/11 downstream ERK phosphorylation and YAP dephosphorylation.
| M.Wt | 462.682 | |
| Formula | C29H42N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jun-Jie Deng, et al. Eur J Med Chem. 2022 Jun 11;239:114520.
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