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Chemical Structure : GRP-60367
Catalog No.: PC-72433Not For Human Use, Lab Use Only.
GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains.
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GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains.
GRP-60367 did not detect morphological signs of cytotoxicity or altered cell metabolic activity after prolonged 48-h exposure of cells to up to 300 uM.
GRP-60367 shows inhibitory activity against fully replication-competent RABV-SAD-B19 (EC50=0.27 uM), rRABV-CVS-N2c is approximately 10-fold less sensitive (EC50=2.63 uM) and the bat isolate is unsensitive (10 uM highest).
GRP-60367 efficiently inhibited the chimeric recVSV-ΔG-eGFP-GRABV virus (EC50=5 nM).
GRP-60367 blocks RABV G protein-mediated viral entry.
| M.Wt | 353.466 | |
| Formula | C21H27N3O2 | |
| Appearance | Solid | |
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1. Venice Du Pont, et al. J Virol. 2020 Jun 16;94(13):e00321-20.
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