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Chemical Structure : GS-493
Catalog No.: PC-61272Not For Human Use, Lab Use Only.
GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.
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GS-493 (GS493) is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay.
GS-493 displays 29- and 45-fold selectivity against related SHP1 and PTP1B.
GS-493 blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar.
GS-493 inhibits tumor growth in murine xenograft model.
| M.Wt | 510.437 | |
| Formula | C21H14N6O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26.
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