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Chemical Structure : GSK-1
Catalog No.: PC-62336Not For Human Use, Lab Use Only.
GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM.
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GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM; induces monopolar spindle formation in SKOV3 cells, and shows markedly greater potency (IC50 of 0.5 nM) in the ispinesib-resistant HCT116-D130V cell line.
| M.Wt | 291.273 | |
| Formula | C16H12F3NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Luo L, et al. Nat Chem Biol. 2007 Nov;3(11):722-6.
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