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Chemical Structure : GSK2643943A
CAS No.: 2449301-27-1
Catalog No.: PC-20184Not For Human Use, Lab Use Only.
GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | $698 | In stock | |
| 1 g | Get quote |
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GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho).
GSK2643943A blocked the USP20-mediated cleavage of protein-ubiquitin bonds.
GSK2643943A (1 uM) influences oHSV-1 T1012G productive infection and viability in SCC9 cells.
GSK2643943A treatment potentiated oHSV-1-induced oncolysis in SCC9 tumors.
GSK2643943A treatment boosted the anti-tumor effects of oHSV-1 T1012G in SCC7 tumors in mice.
| M.Wt | 277.30 | |
| Formula | C17H12FN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-2-amino-6-(3-fluorostyryl)-1H-indole-3-carbonitrile |
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1. Lu R, et al. Mol Ther Oncolytics. 2021 Nov 11;23:477-487.
2. Mark Kemp. Prog Med Chem. 2016; 55: 149–192.
3. Biju M, et al. Discovery of potent and selective small molecule USP20 inhibitors. Poster presented at ubiquitin drug discovery and diagnostics, Philadelphia; 2012.
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