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Chemical Structure : GSK2818713
Catalog No.: PC-72397Not For Human Use, Lab Use Only.
GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.
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GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.
GSK2818713 significantly improved genotype coverage relative to first-generation NS5A inhibitor daclatasvir (DCV).
GSK2818713 improved activity against genotype 1a (gt1a) and gt1b NS5A variants as well as HCV chimeric replicons containing NS5A fragments from genotypes 2-6.
GSK2818713 potently and durably decreased HCV RNA levels for gt1a, gt2a, and gt3a in replicon assays.
| M.Wt | C46H56N8O8 | |
| Formula | 849.002 | |
| Appearance | Solid | |
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1. Wieslaw M Kazmierski, et al. J Med Chem. 2020 Apr 23;63(8):4155-4170.
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