Chemical Structure : GSK3β-Nav1.6 inhibitor 1063
CAS No.:
321530-08-9
GSK3β-Nav1.6 inhibitor 1063
Catalog No.: PC-25144Not For Human Use, Lab Use Only.
GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner.
Compound 1063 is functionally specific for Nav1.6 over other central nervous system (CNS) Nav isoforms.
Compound 1063 reduces hippocampal hyperexcitability through a GSK3β-dependent mechanism and dose-dependently suppresses epileptiform spikes in early-stage AD mouse models.
Physicochemical Properties
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M.Wt
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338.47
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Formula
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C17H26N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 2-(2-(isopropylamino)acetamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
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References
1. Baumgartner TJ, et al. Alzheimers Dement. 2025 Jul;21(7):e70507.
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