Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GSK620
CAS No.: 2088410-46-0
Catalog No.: PC-72179Not For Human Use, Lab Use Only.
GSK620 (GSK-620) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.1 (BRD4 BD2), 220-fold selectivity over BD1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GSK620 (GSK-620) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.1 (BRD4 BD2), 220-fold selectivity over BD1.
GSK620 significantly and dose-dependently inhibited both the arthritic score and IgG1 production in response to the immunisation in collagen-induced arthritis model in rats, showed similar level of efficacy to the pan-BET inhibitor I-BET151 and also dramatically reduced joint swelling, synovitis, cartilage damage, pannus formation and bone resorption.
| M.Wt | 325.37 | |
| Formula | C18H19N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide |
|
1. Gilan O, et al. Science. 2020 Apr 24;368(6489):387-394.
2. Seal JT, et al. J Med Chem. 2020 Sep 10;63(17):9093-9126.
3. Aylott HE, et al. J Med Chem. 2021 Mar 25;64(6):3249-3281.
4. Rianjongdee F, et al. J Med Chem. 2021 Aug 12;64(15):10806-10833.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
