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GSK699

Chemical Structure : GSK699

CAS No.: 2260944-68-9

GSK699 (GSK-699;GSK 699)

Catalog No.: PC-35667Not For Human Use, Lab Use Only.

GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells.

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    Biological Activity

    GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells.
    GSK699 also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs).
    GSK699 potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.

    Physicochemical Properties

    M.Wt 895.856
    Formula C45H51BrN8O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-((3R,5R)-5-((5-bromo-1-methyl-6-oxo-1,6-dihydropyridazin-4-yl)amino)-1-methylpiperidin-3-yl)-N-(3-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propyl)phenyl)(methyl)amino)propyl)-N-methylbenzamide

    References

    1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.

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