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GSK898

Chemical Structure : GSK898

CAS No.: 1953156-92-7

GSK898 (GSK-898)

Catalog No.: PC-20933Not For Human Use, Lab Use Only.

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.
GSK898 shows no inhibitory effects on the other enzymes in the tryptophan metabolism pathway (IDO, TDO, KATI/II, kynureninase).
GSK898 rescues the phenotype, reducing 3-hydroxykynurenine and protecting against critical illness and death.

Physicochemical Properties

M.Wt 360.79
Formula C18H17ClN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(O)CCC1=NOC2=CC(O[C@@H](C3=NC=C(C)C=C3)C)=C(Cl)C=C12

References

1. Alastair J Hayes, et al. Cell Rep. 2023 Jul 19;42(8):112763.

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