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Chemical Structure : GSK983
Catalog No.: PC-35668Not For Human Use, Lab Use Only.
GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.
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GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively
GSK983 also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs).
GSK983 potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.
| M.Wt | 895.856 | |
| Formula | C45H51BrN8O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.
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