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Chemical Structure : GW-4064
CAS No.: 278779-30-9
Catalog No.: PC-45825Not For Human Use, Lab Use Only.
GW-4064 (GW4064) is a potent and selective FXR agonist with EC50 of 15 nM in cell-free assay, >200-fold more potent than CDCA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GW-4064 (GW4064) is a potent and selective FXR agonist with EC50 of 15 nM in cell-free assay, >200-fold more potent than CDCA.
GW-4064 has an EC50 of 80 and 90 nM, respectively, in CV-1 cells transfected with mouse and human FXR expression vectors.
GW-4064 significantly reducess serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage in rat models of cholestasis.
| M.Wt | 542.8376 | |
| Formula | C28H22Cl3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]- |
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1. Maloney PR, et al. J Med Chem. 2000 Aug 10;43(16):2971-4.
2. Liu Y, et al. J Clin Invest. 2003 Dec;112(11):1678-87.
3. Kast HR, et al. J Biol Chem. 2002 Jan 25;277(4):2908-15.
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