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GW406108X

Chemical Structure : GW406108X

CAS No.: 1644443-92-4

GW406108X (GW-406108X;GW108X)

Catalog No.: PC-35945Not For Human Use, Lab Use Only.

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays; GW108X displays a preference for Kif15 over the other mitotic motors, with 30 µM of GW108X inhibiting Kif15 MT gliding by 98.9% ± 0.2% while only inhibiting Eg5 by 19.8% ± 4.3%, HSET by 5.3% ± 2.9% and Kif18A by 4.9%; inhibits the MT-stimulated ATPase and MT gliding activity of Kif15 either by inhibiting ATP binding or by inhibiting MT binding by the motorl; shows a distinct mechanism of action compared with the Kif15 inhibitor, Kif15-IN-1.

Physicochemical Properties

M.Wt 400.211
Formula C20H11Cl2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-3-(3,5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one

References

1. Dumas ME, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):148-154.

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