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Chemical Structure : Gefitinib-based PROTAC 3
Catalog No.: PC-35357Not For Human Use, Lab Use Only.
Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R)..
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Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
| M.Wt | 934.522 | |
| Formula | C47H57ClFN7O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.
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