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Chemical Structure : Gefitinib
CAS No.: 184475-35-2
Catalog No.: PC-45891Not For Human Use, Lab Use Only.
Gefitinib (ZD-1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $78 | In stock | |
| 200 mg | $118 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Gefitinib (ZD-1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
Gefitinib (ZD-1839) inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
Gefitinib (ZD-1839) blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM.
Gefitinib (ZD-1839) significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth.
Gefitinib (ZD-1839) has been used to treat advanced (or recurrent) non-small cell lung cancer.
| M.Wt | 446.9024 | |
| Formula | C22H24ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]- |
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1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
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