Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Gefitinib hydrochloride
CAS No.: 184475-55-6
Catalog No.: PC-45892Not For Human Use, Lab Use Only.
A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 mg | $48 | In stock | |
| 1 g | $60 | In stock | |
| 5 g | $120 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM; blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM; significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth; has been used to treat advanced (or recurrent) non-small cell lung cancer.
Lung Cancer
Approved
| M.Wt | 483.3633 | |
| Formula | C22H25Cl2FN4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 0.227 mg/mL; H2O：< 4.8 mg/mL |
|
| Chemical Name/SMILES |
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:1) |
|
1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
