Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Gemilukast
Catalog No.: PC-35978Not For Human Use, Lab Use Only.
Gemilukast (ONO-6950, ONO6950) is a potent, orally active, dual CysLT1 and CysLT2 antagonist with IC50 of 1.7 and 25 nM against human CysLT1 and human CysLT2, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Gemilukast (ONO-6950, ONO6950) is a potent, orally active, dual CysLT1 and CysLT2 antagonist with IC50 of 1.7 and 25 nM against human CysLT1 and human CysLT2, respectively; antagonized intracellular calcium signaling via human and guinea pig CysLT1 and CysLT2 receptors with IC50 values of 1.7 and 25 nM, respectively (human receptors) and 6.3 and 8.2 nM, respectively (guinea pig receptors); attenuated CysLT1-mediated bronchoconstriction and airway vascular hyperpermeability induced by LTD4 in normal guinea pigs (1 or 0.3 mg/kg, p.o.), strongly inhibited this asthmatic response to the level attained by combination therapy with montelukast and BayCysLT2RA.
Asthma
Phase 2 Discontinued
| M.Wt | 601.69 | |
| Formula | C36H37F2NO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Itadani S, et al. J Med Chem. 2015 Aug 13;58(15):6093-113.
2. Yonetomi Y, et al. Eur J Pharmacol. 2015 Oct 15;765:242-8.
3. Gauvreau GM, et al. Allergy. 2016 Dec;71(12):1721-1727.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
