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Chemical Structure : Genz-123346
Catalog No.: PC-43171Not For Human Use, Lab Use Only.
Genz-123346 is a potent, specific glucosylceramide synthase inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity.
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Genz-123346 is a potent, specific glucosylceramide synthase inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity; effectively inhibits GL1 synthase activity and does not significantly elevate cell ceramide levels in vitro, lowers glucose and A1C levels , and improves glucose tolerance in the Zucker diabetic fatty rats; effectively inhibits cystogenesis in mouse models of polycystic kidney disease (PKD).
| M.Wt | 987.2259 | |
| Formula | C52H82N4O14 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao H, et al. Diabetes. 2007 May;56(5):1210-8.
2. Zhao H, et al. Hepatology. 2009 Jul;50(1):85-93.
3. Natoli TA, et al. Nat Med. 2010 Jul;16(7):788-92.
4. Chai L, et al. Int J Oncol. 2011 Mar;38(3):701-11.
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