Girolline | eIF5A modulator | Probechem Biochemicals

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Chemical Structure : Girolline

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Girolline (Girodazole)

Catalog No.: PC-23755Not For Human Use, Lab Use Only.

Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	190.63
Formula	C6H11ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-3-amino-1-(2-amino-1H-imidazol-4-yl)-2-chloropropan-1-ol

References

1. Schneider-Poetsch T, et al. Nat Commun. 2025 Jan 10;16(1):223.

2. Fung SY, et al. ACS Chem Biol. 2014 Jan 17;9(1):247-57.

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Girolline (Girodazole)

Biological Activity

Physicochemical Properties

References

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