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Chemical Structure : Glecaprevir
Catalog No.: PC-61941Not For Human Use, Lab Use Only.
Glecaprevir (ABT 493.
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Glecaprevir (ABT 493;A 1282576) is a novel HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM; inhibits the replication of stable HCV subgenomic replicons genotypes 1-6 with EC50 of 0.21-4.6 nM, has a median EC50 of 0.30 nM (0.05 - 3.8 nM) for HCV replicons containing proteases from 40 HCV genotype 1-5 samples; the combination of ABT-493 and ABT-530 demonstrates potent antiviral activity and acceptable safety in clinical trails with HCV genotype 1 infection.
HCV Infection
Phase 2 Clinical
| M.Wt | 838.87 | |
| Formula | C38H46F4N6O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lawitz EJ, et al. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1546-55.
2. Gane E, et al. Gastroenterology. 2016 Oct;151(4):651-659.e1.
3. Poordad F, et al. Hepatology. 2017 Aug;66(2):389-397.
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