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Chemical Structure : Glutamate-cysteine ligase inhibitor EN25
Catalog No.: PC-21231Not For Human Use, Lab Use Only.
Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL.
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Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL.
Glutamate-cysteine ligase inhibitor EN25 inhibits GCL activity, lowers cellular GSH levels, and impairs cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells.
| M.Wt | 416.54 | |
| Formula | C25H24N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lydia Zhang, et al. Chembiochem. 2023 Sep 27;e202300371.
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