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Chemical Structure : Golgicide A
CAS No.: 1139889-93-2
Catalog No.: PC-62234Not For Human Use, Lab Use Only.
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.
Golgicide A causes complete dispersal of the medial-Golgi markers giantin and the cis-Golgi marker GM130
Golgicide A causes a decrease in GBF1-mediated Arf1 activation; inhibits swine vesicular disease virus (SVDV) procution.
| M.Wt | 284.31 | |
| Formula | C17H14F2N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline |
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1. Sáenz JB, et al. Nat Chem Biol. 2009 Mar;5(3):157-65.
2. Ignashkova TI, et al. Traffic. 2017 Aug;18(8):530-544.
3. Vázquez-Calvo Á, et al. Front Microbiol. 2016 Apr 27;7:612.
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