Chemical Structure : Greatwall inhibitor C-604
CAS No.:
Greatwall inhibitor C-604
(UOS-00054604)
Catalog No.: PC-25465Not For Human Use, Lab Use Only.
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays.
C-604 inhibits GWL in a non-stereospecific manner.
C-604 treatment (0-4 uM) resulted in gradual dephosphorylation of ENSA(S67) and ARPP19(S62) in prometaphase-arrested HCC1395 (breast cancer), U2OS (osteosarcoma), RPE-1 (non-transformed) and HeLa (cervical cancer) cells.
C-604 (2 uM) demonstrates strong cytostatic properties, effectively inhibiting colony formation in RPE-1 and HeLa cells exposed to the compound for 72 h.
C-604 causes pleiotropic B55α-dependent cellular pathologies, acts on-target and interferes with the PP2A-B55/ENSA/GWL regulatory axis.
Physicochemical Properties
|
M.Wt
|
441.54
|
|
Formula
|
C26H27N5O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-methyl-2-(4-(2-(3-phenylpyrrolidin-1-yl)ethoxy)phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
|
References
1. Zach R, et al. Nat Commun. 2025 Aug 27;16(1):8016.
Contact Us
sales@probechem.com
