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Chemical Structure : Gue-1654
Catalog No.: PC-70005Not For Human Use, Lab Use Only.
Gue-1654 (GUE 1654) is a small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R (Oxoeicosanoid receptor) in both recombinant and human primary cells.
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Gue-1654 (GUE 1654) is a small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R (Oxoeicosanoid receptor) in both recombinant and human primary cells.
Gue-1654 blocks β-arrestin2 recruitment in HEK293 cells overexpressing OXE-R and ERK1/2 phosphorylation in human eosinophils and neutrophils.
Gue-1654 is the first small-molecule inhibitor for the oxoeicosanoid receptor (OXE-R) and the first probe to uncouple Gα and Gβγ signaling within a heterotrimer for any GPCR.
| M.Wt | 447.589 | |
| Formula | C23H17N3OS3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Blättermann S, et al. Nat Chem Biol. 2012 Jul;8(7):631-8.
2. Konya V, et al. J Immunol. 2014 May 15;192(10):4774-82.
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