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Chemical Structure : H203
Catalog No.: PC-38074Not For Human Use, Lab Use Only.
H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.
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H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.
H203 significantly reduced cell viability in the cells overexpressing both Mdm2 and MdmX, and a significant and dose-dependent decrease in cell number in H203-treated cells lacking Mdm2 or MdmX.
H203-mediated decrease in cell viability is strictly p53-dependent and H203 affects MdmX more specifically than nutlin-3a.
H203 induced the expression of the p21 gene but not the p53 gene in treated cancer cells.
| M.Wt | 667.547 | |
| Formula | C35H28Cl2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiyao Cheng, et al. Nat Commun. 2022 Feb 28;13(1):1087.
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