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Chemical Structure : H3B-120
CAS No.: 2194903-42-7
Catalog No.: PC-38214Not For Human Use, Lab Use Only.
H3B-120 (H3B 120) is a selective allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with Ki of 1.4 uM, does not bind to CPS2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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H3B-120 (H3B 120) is a selective allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with Ki of 1.4 uM, does not bind to CPS2。
H3B-120 demonstrated complete inhibition of both ATP activity and carbamoyl phosphate synthetase activity of CPS1 with IC50 of 1.5 uM.
H3B-120 blocks pyrimidine labeling in hepatocytes treated with 15N-ammonia, inhibits urea production in a dose-dependent manner, although the cellular potency decreased significantly compared with enzymatic assays.
| M.Wt | 372.487 | |
| Formula | C19H24N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N1-benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide |
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1. Yao S, et al. Cell Chem Biol. 2020 Mar 19;27(3):259-268.e5.
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